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Medications

Abacavir; Dolutegravir; Lamivudine tablets

What is this medicine?

ABACAVIR; DOLUTEGRAVIR; LAMIVUDINE (a ba KA vir; doe loo teg ra veer; la MI vyoo deen) is three antiretroviral medicines in one tablet. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You may take this medicine with or without food. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • cough

  • fever

  • muscle or joint pain

  • nausea, vomiting, unusual stomach upset or pain

  • pain, tingling, numbness in the hands or feet

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • sore throat

  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • dizziness

  • headache

  • trouble sleeping

  • weight gain around waist, back, or thinning of face, arms, legs

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • any other medicine that contains abacavir or lamivudine

  • any medicine that contains emtricitabine

  • dofetilide

This medicine may also interact with the following medications:

  • alcohol or alcohol containing products

  • antiviral medicines for HIV or AIDS like efavirenz, etravirine, nevirapine, fosamprenavir/ritonavir, tipranavir/ritonavir

  • buffered medicines, like buffered aspirin

  • calcium supplements

  • certain antacids

  • certain laxatives

  • certain medicines for seizures like carbamazepine, oxcarbazepine, phenytoin, phenobarbital

  • interferon

  • iron supplements

  • metformin

  • methadone

  • nelfinavir

  • ribavirin

  • rifampin

  • St. John's Wort; Hypericum perforatum

  • sucralfate

  • sulfamethoxazole; trimethoprim, SMX-TMP

What if I miss a dose?

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 4 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • drink alcohol-containing drinks

  • heart disease

  • kidney disease

  • liver disease

  • smoke tobacco

  • an unusual or allergic reaction to abacavir, dolutegravir, lamivudine, other medicines, lactose, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

If you have hepatitis B and HIV, talk to your doctor if you plan to stop this medicine. The symptoms of hepatitis B may get worse if you stop this medicine.

A small number of people may have a severe allergy to this medicine. Some symptoms are a skin rash, fever, nausea, vomiting, stomach pain, severe tiredness, aches, or generally feeling sick. A list of these symptoms is on the Warning Card given to you by your pharmacist. You should carry this Warning Card with you. If you have these symptoms while taking this medicine, stop the medicine and call your doctor right away.

If you stop this medicine because you ran out of medicine or because you may have had an allergic reaction, talk to your doctor. Do not restart this medicine without your doctor's advice. Severe hypersensitivity reactions can occur within hours and may include life-threatening hypotension and death.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2017 Elsevier